The best approach is usually the one that feels sustainable enough to stick with long after the excitement of starting something new wears off
Drinking water and other healthy fluids can also help metabolize the drug through your system
Even with supplementation, fatigue may persist if other issues exist, such as: Iron deficiency Vitamin D insufficiency Thyroid imbalance Chronic stress or poor sleep Blood sugar instability This is why guessing supplements without checking levels can waste time
For suspected macro-B12, precipitation with PEG is the test most often reached for, though it is nonspecific and can remove B12 that is fully available to cells, so direct measurement of the binding proteins, haptocorrin and transcobalamin, may be more informative when it is available
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