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While this appetite reduction facilitates caloric restriction, it creates a nutritional challenge: many patients struggle to consume adequate protein despite increased physiological needs during active weight loss

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(Side effects include nausea, diarrhea, vomiting, abdominal pain, and constipation.) Semaglutide and tirzepatide were initially created to treat type 2 diabetes

Take home message Mounjaro (tirzepatide) produces significantly more weight loss than liraglutide (Saxenda/Nevolat) in clinical trials: approximately 1521% versus 8% over similar timeframes