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Compared with the sham group, there was a significant increase in TG, TC and LDL-C levels and a decrease in HDL-C levels in the DMM group

The absence of effects on IGF-1, glucose metabolism, and tissue growth reduces concerns about long-term hormonal consequences, but prudent medical oversight remains appropriate for any extended peptide use

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CNS-targeted formulations will require blood-brain barrier penetration profiling, while cardiac endpoints demand longer stability windows

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes