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The PGC-1-Nrf1 axis also stimulates the transcription of mitochondrial gene-encoded factors, including mitochondrial transcription factor B1 (TFB1M), TFB2M, and mitochondrial transcription factor A (TFAM), which mediate mtDNA replication and transcription [23]
Notably, nanomedicine or delivery-based approaches are also being explored to co-administer ferroptosis-inducing drugs with FSP1 inhibitors, highlighting a practical path for improving tumor-selective exposure and therapeutic index in vivo 123
Cross-linking of collagen and elastin
[60] Resveratrol can regulate the downregulation of inflammatory genes, such as insulin-like growth factor-1, and, hence, is promising in endometriosis and uterine fibroids
Users have reported firmer, more radiant skin from the first applications, thanks to its protective and revitalising effect
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