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Special Dosing Situations for Severe B12 Deficiency In cases of severe Vitamin B12 deficiency, special dosing is key for treatment

This is why Im in favor of a comprehensive prenatal vitamin in lieu of supplementing individual nutrients, and part of the reason Im especially cautious with folic acid supplementation (methylfolate is a much wiser choice

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For most patients, weekly or bi-weekly B12 injections provide the best results

The conversion of homocysteine to methionine requires the availability of choline or folic acid to provide methyl groups, so when folic acid is deficient, cells metabolize more choline, resulting in a deficiency of phosphatidylcholine, a key component of mycelin