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01Mechanism of action Tesamorelin is a complete synthetic analog of native human GHRH (44 amino acids), modified by adding a trans-3-hexenoic acid group at the N-terminal position

The FDA's labeling for somatropin-class agents (rhGH) explicitly warns of new-onset type 2 diabetes, and the same biological mechanism applies to GHRH analogs that raise GH [10]

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Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS et al