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The GIP receptor plays an important role in regulating insulin and appetite, providing an additional mechanism for improved blood sugar control and appetite suppression

The diuretic and natriuretic effects of GLP-1 are mediated through downregulation of sodiumhydrogen exchanger 3 (NHE3) activity in the renal proximal tubule that consequently affects renal hemodynamics [112]

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The GLP-1 and GIP receptors play essential roles in augmenting insulin secretion and glucose homeostasis, whereas GCG receptor engagement elevates circulating GCG levels, promoting catabolic processes

Protein Intake and Muscle Preservation Nunes EA et al