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In pediatric rhabdoid tumors (RTs), which often lack targetable mutations, a combined high-throughput drug screen and genome-scale CRISPR-Cas9 knockout study identified receptor tyrosine kinases (RTKs) and the downstream signaling protein SHP2 (encoded by PTPN11) as essential for tumor survival despite the absence of genetic alterations, highlighting non-mutational dependencies [118]

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High-dose oral B12 can still be effective for those with mild absorption problems

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Larish served as the former chief resident of Urology at Lenox Hill Hospital

To date, approximately fifteen marine-derived compounds (MDCs) have been approved for clinical use (e.g., Carragelose, Retrovir, Prialt, and Yondelis) (Proksch et al., 2003