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In a myocardial infarctioninduced depression model, Ginkgolide B lowered IL1 via the STAT3 pathway and raised 5HT, supporting the concept that antiinflammatory interventions can normalize neurotransmitter imbalances [20]

Anti-inflammatory and analgesic properties of Ocimum sanctum : a comparative study using animal models

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While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)

Most applications remain exploratory without robust long-term safety data in specific populations

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