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semaglutide at 1 mg weekly at least during the 6 last months of follow-up (78.9%) had better results, in terms of HbA1c and body weight decrease, than those who had not reached the full dose at the end of the study (EOS)

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In contrast to genetic mutations, epigenetic modifications rapidly affect target cell types exerting a long-lasting control in gene expression and provide a mechanism for a non-genomic inheritance