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This is done when a substantial body of research shows that a drug can help with conditions beyond what theyve been initially approved for by the FDA

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This biased agonism refers to the fact that tirzepatide selectively engages cAMP signaling over -arrestin recruitment at the GLP-1R, which may augment cellular response via beneficial impact on GLP-1R cell surface trafficking, leading to increased cell surface expression

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Key milestones include appetite reduction within the first week, steady weight loss beginning in week 2-3, and established meal routines by month two