Per a 2021 analysis published in Diabetes Obesity Metabolism , nearly 50% of patients on semaglutide report nausea.41 Side effects tend to be dose dependent and may lessen in intensity with ongoing treatment.42,43 An underlying cause for these GI complaints relates to one of the ways in which GLP-1 medications work, which involves delayed gastric emptying
This side effect was common in clinical studies of the drug
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Additional tests in mice showed that semaglutide also blunted the increase in locomotor activity caused by cocaine, a behavior often used as a proxy for the drugs stimulant effects
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