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While weight loss can occur on GLP-1 medications without exercise , adding resistance training helps preserve lean muscle mass and improves metabolic health outcomes beyond what medication alone achieves

GLP-1 receptor agonists provide better glycemic status and body weight control

The weight loss observed with orforglipron is attributed to its ability to decrease appetite and enhance satiety, alongside its positive effects on glucose metabolism

Also, the incidences of thrombotic events increase with age

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