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Embora muitos desses achados sejam provenientes de estudos in vitro , modelos experimentais e pesquisas pr-clnicas, eles contriburam para consolidar o GHK-Cu como um dos peptdeos bioativos mais estudados da dermatologia moderna

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Special attention should be paid to the amount of free hormone that is available to tissues based on the binding affinities of estrone (E1), estradiol (E2), estriol (E3) and 16-alpha-hydroxyestrone at the estrogen receptors