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It is also being studied as a potential treatment for non-alcoholic steatohepatitis (NASH) and heart failure with preserved ejection fraction (HFpEF)

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Some patients feel an energy boost within a few days, while others with severe neurological symptoms may take several weeks of treatment before noticing improvement

This makes insulin come out and glucagon levels drop

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Conversely, variants associated with lower baseline receptor sensitivity may require higher doses or progression to dual-mechanism compounds like tirzepatide