Pharmacol, Biochem Behav 89:56371
Another contributing factor is altered bile composition, often linked to rapid weight loss
Pathways to cardiovascular benefit with GLP-1 receptor agonists: beyond glucose lowering
Other Side Effects Muscle pain (due to fasciculations) Increased intragastric pressure aspiration risk Increased intraocular pressure (contraindicated in glaucoma) Pharmacokinetics Routes: IV or IM Rapid metabolism by plasma pseudocholinesterase Not metabolized by acetylcholinesterase Key Parameters: Onset: 3060 seconds Duration: 610 minutes Half-life: 35 minutes Notes: Phase II block recovery may last 30 minutes or longer Duration depends on: Rate of receptor dissociation Plasma enzyme activity Drug Interactions Increase Duration of Action: Cholinesterase inhibitors (e.g., neostigmine , pyridostigmine ) Administration of neostigmine & pyridostigmine to patients to reverse non-depolarizing skeletal muscle blockade has been shown to cause profound reductions of plasma pseudocholinesterase activity for several hours duration (Mirakhur et al, 1982), an effect that can mechanistically account for the observed prolongation of succinylcholine effect by these cholinesterase inhibitors (Sunew & Hicks, 1978
For more in-depth support, our telehealth video visits connect you with real doctors for less than $40
Bupropion (Zyban) is licensed in the UK as an aid to smoking cessation, whilst Saxenda (liraglutide 3 mg) is approved for weight management in adults with obesity or overweight with weight-related comorbidities
