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Whereas the AP lies outside the bloodbrain barrier and has a high density of Gipr -expressing cells, most of which are GABAergic, many Gipr -expressing neurones in the hypothalamus have their cell bodies behind the bloodbrain barrier and include both glutamatergic and GABAergic neurons 16

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"Distribution of ADH2 and ALDH2 genotypes in different populations"

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However, only about half of people with PA have these IFAB