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Issues such as low aqueous solubility, batch-to-batch variability of botanical extracts, and the absence of robust pharmacokinetic and pharmacodynamic data in humans continue to limit their direct comparability with synthetic agents [37,38,39]
It usually takes 24 weeks of consistent use to notice meaningful changes
A 2015 review of peptide hormone pharmacokinetics published in Clinical Pharmacology & Therapeutics confirmed that "peptides of fewer than 40 amino acids are predominantly cleared through proteolytic degradation rather than hepatic oxidative metabolism, making traditional CYP-mediated drug interactions clinically irrelevant for this class" [5]
References: DSIP
76.Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM
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