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Information on each adverse event (AE) and serious AE (SAE) was recorded via an electronic case report form, which also required the investigator to assess any possible relationship between the AE and the study treatment

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The underlying mechanism generally consists of the oxidation of redox-reacting cysteine and/or tyrosine residues located within or near the active site, which creates intraprotein and interprotein bridges that affect protein function 8,9

JCI Insight 4(5):e126742