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At 48 weeks, the high-dose combination (bimagrumab 30 mg/kg + semaglutide 2.4 mg) achieved a mean weight reduction of 17.8 kg, exceeding semaglutide alone (14.2 kg)

They were initially developed as diabetes treatments but have more recently been repurposed for obesity management

Realistic skin improvements begin appearing around week 4-6 as the first collagen remodeling cycle completes and continues improving through week 12 and beyond

Am J Psychiatry 152 : 213219

Bottom line: For a 10 mg vial of tirzepatide, 1 mL of bacteriostatic water is the standard diluent amount, resulting in a concentration of 1 mg per 10 units on a U-100 syringe