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This mechanism relies on the role of ECM synthesized by cellular components and the communication between these components and cancer cells

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Randomised withdrawal trials in this class consistently show substantial weight regain after discontinuation, and a 2026 review in EClinicalMedicine reports that roughly two-thirds of lost weight is typically regained within a year of stopping

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10.1007/s00213-011-2624-6 [DOI] [PMC free article] [PubMed] [Google Scholar] Kruegel AC, & Grundmann O (2018)