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Evstratova et al., 2+ ] i to the threshold for induction of long-term plasticity also at heterosynaptic sites within a dendritic branch that is currently most active or over broader regions of the dendritic tree

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Meaning doses lower than what most researchers use may produce comparable neurogenic signaling without the higher systemic exposure

The STEP trials showed continued weight loss improvement at higher doses, with the dose-response relationship remaining positive through 2.4 mg