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Some have been fully vetted by the FDA, including insulin and GLP-1 drugs

2016 Apr;6(2)

References Chang CH, Tsai WC, Lin MS, et al

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The OGD model was used to study taurine analogs/GABA-T inhibitors such as piperidine-3-sulfinic acid (PSA), 2-aminobenzenesulfonate (ANSA) and 2-(N-acetylamino) cyclohexane sulfonic-acids (TAHS)

Metabolic Risk (Lower): Due to its very short half-life (approximately 20 minutes), IGF-1 DES poses a lower risk of sustained, systemic hypoglycemia compared to the long-acting IGF-1 LR3