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References: Almohanna et al

A 2018 meta-analysis found that ALCAR supplementation in humans significantly lowers depressive symptoms compared with placebo or no intervention, and does so with fewer adverse effects than established antidepressants, especially in older adults

This means they lack the quality controls, dosing standardization, and safety monitoring that approved drugs provide

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Nonetheless, the deletion of Nrf2 prevented the increased expression of NRF2 protein and the induction of NRF2 targets upon Gclc deletion in liver tissue (Fig

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