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In preliminary results of OASIS 1, a recent 68-week, phase 3a clinical trial that compared once-daily oral semaglutide with placebo in adults with obesity or overweight with one or more underlying comorbidities, the average weight loss from baseline was 15.1% in the semaglutide group and 2.4% in the placebo group

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The SELECT trial (NEJM, 2023) demonstrated that semaglutide 2.4mg reduced major adverse cardiovascular events (MACE) by 20% in over 17,000 patients with overweight/obesity and established cardiovascular disease, without diabetes

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