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IGF-1 DES binds IGFBP-3 poorly, similar to LR3, but it also has roughly ten-fold higher potency at IGF-1R because the N-terminal tripeptide normally dampens receptor-binding affinity

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3 Composition of gut bacteria and the GBA The composition of gut microbial communities varies among individuals, and approximately 70% of species-level phylogenetic types are distinct to each person (60)

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