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More than one in eight patients on retatrutide were completely free of knee pain by the end of the trial an outcome with meaningful implications for patients whose joint pain is driven or worsened by excess weight

Mechanism of action P21 enhances BDNF signaling and promotes neurogenesis in the hippocampus, the brain region most critical for memory formation

de Athayde De Hollanda, A

Weight management itself influences GLP-1 function

Cooper M, Martin J, Langley K, Hamshere M, Thapar A

It can be used to treat gastroesophageal reflux disease (GERD) and gastroparesis, and to reduce the risk of aspiration in patients with dysphagia