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Lixisenatide (Adlyxin) is dosed once daily 60 minutes prior to a meal and must be titrated

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Tier 3: vitamin D, B12, and iron, supplemented only after bloodwork confirms a shortfall

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The time course of peptide degradation was determined by integrating the area of each peak in a series of HPLC traces

Blood pressure (BP), anthropometric characteristics, markers of liver function, metabolic indices (plasma glucose, lipid profiles, uric acid, free fatty acid and insulin) and hypersensitivity C-reactive protein were measured