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Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

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Through Epac/PI3K/Akt, cAMP/PKA, and AMPK/SIRT1 signaling, they enhance mitochondrial function, autophagy, and metabolic reprogramming, collectively preserving genome integrity, proteostasis, and systemic homeostasis to promote healthy aging

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Targeting of CXXC5 by a competing peptide stimulates hair regrowth and wound-induced hair neogenesis