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More concerning still, the prevalence of severe obesity, defined as a BMI 35 kg/m 2 with at least one comorbidity or a BMI 40, was 9.7% [6]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Portenoy R.K., Ganae-Motan E.D., Allende S., Yanagihara R., Shaiova L., Weinstein S., McQuade R., Wright S., Fallon M.T

The clinical trials have shown that SGLT-2i reduced NPDR progression in T2DM patients with hypertension, likely due to its anti-inflammatory and hemodynamic effects (104, 105)