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Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph+ Cml

PMID: 199 Lo ConteMCosorichIFerrareseRCencicchioMANobiliAPalmieriVet al

Within the first few days, the constant, throbbing background noise of pain usually quiets down

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

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