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This highlights the importance of a full-carbon framework to facilitate geometrical isosterism but allows the opportunity to modulate the angles within the naphthyl isostere framework

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Guo W, Bachman E, Li M, Roy CN, Blusztajn J, Wong S, Chan SY, Serra C, Jasuja R, Travison TG, Muckenthaler MU, Nemeth E, Bhasin S

This leads to the inflammation (redness and swelling) of acne

PMID: 41490200 | doi:10.5435/JAAOSGlobal-D-25-00236 Mayfield CK et al

This rigorous analysis wasn't restricted to just one location

28 NAPQI has been shown to modify cysteine residues of the Kelch-like ECH-associated protein 1 (Keap1) protein, activating the Keap1-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway