For weight management (NICE TA875 for semaglutide 2.4mg/Wegovy and TA664 for liraglutide 3mg/Saxenda): Treatment should be discontinued if specific weight loss targets are not met (typically at least 5% of initial body weight at 12-16 weeks)
however, their effects on sexual health remain ambiguous
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Nevertheless, in 2021, the FDA offered an additional approval for 2.4 mg of SEM, administered once a week subcutaneously, as an adjunct able to reduce caloric intake in individuals diagnosed with obesity (BMI higher than 30 kg/m 2 or higher than 27 kg/m 2 with at least one comorbidity related to weight) [10,21,22]