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Retatrutide is exciting, but it is still in trials, and its long-term impact remains unknown

Another issue regarding adrenal function in PWS is the presence of premature pubarche, reported in the literature with a very variable prevalence, from 14% to 60% (6673)

This fragmentation can quickly undermine convenience and adherence, suggesting that long-term DTP success will depend not only on access and affordability, but on how well these models support a seamless, holistic medication experience