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Higher percentages of participants had reductions in body weight of 10% or more and 15% or more with retatrutide (all doses) than with placebo

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combination designs, sex-stratified analyses, PK-informed formulations for polyphenols, and developmentally sensitive timing

The choice of a C18 fatty acid in retatrutide contrasts with the C20 (eicosanedioic acid) fatty diacid used in tirzepatide

10.1016/S2213-8587(22)00008-0 33