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The peptide is thought to stimulate the activity of telomerase , an enzyme that helps preserve the structure of telomeres

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50 However, TGF- also downregulates the lymphangiogenic function of collagen and calcium-binding EGF domain-1 (CCBE1) in cancerassociated fibroblasts (CAFs) and colorectal cancer cells by directly binding Smads to the CCBE1 gene locus

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