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Auranofin shows an additive effect with COJEC chemotherapy Because the antagonism observed between RSL3 and COJEC appears to be mediated by GPX4 upregulation, we decided to test COJEC in combination with a ferroptosis-inducing agent with a different MOA, the TrxR inhibitor Auranofin

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For some peptides, metabolites remain detectable days after the parent compound has completely cleared

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Second, from Table 1, it is clear that the higher is the baseline A1c, the more likely are the two drugs (when administered as monotherapy) to produce an additive decrement in A1c that is greater than when the two drugs are administered as combined therapy