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Importantly, none of the trials in T1D reported an increase in diabetic ketoacidosis (DKA) a key concern that has limited the use of SGLT2 inhibitors in T1D

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One study found that a year after stopping treatment, participants gained about 67% of the weight back

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However, it should be appreciated that this severe complication is rare and the risk is also less with endoscopy compared with surgical procedures that require general anesthesia (38)

Finally, although higher circulating levels of lipase and amylase were reported in patients on GLP-1 RA therapy in many trials, the increases were rarely higher than three or five-fold the upper limit of normal (ULN), respectively [9,10,11,12,13,14,15,16,17], returned to normal levels after medication withdrawn, and were poor predictors of AP [54]