Quantitative proteomics revealed that cells treated with sublethal doses of Fento-1 for 48 h promoted the upregulation of ferroptosis 1,36 and lysosome-associated proteins, including ferroptosis suppressors and lysosome-associated membrane proteins (LAMPs), respectively, a result that provides support for the role of lysosomes in ferroptosis induction (Fig
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A second delivered viral vector, which is activated by the antibiotic drug doxycycline, will code for a protein that activates the first vector, making doxycycline akin to a safety switch
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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig
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