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Exendin-4 is a high potency agonist and truncated exendin-(939)-amide an antagonist at the glucagon-like peptide 1-(736)-amide receptor of insulin-secreting beta-cells

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Seek immediate medical attention (call 999 or attend A&E) if you have severe pain uncontrolled by over-the-counter analgesia, high fever (above 38C) with loin pain, inability to pass urine, or persistent vomiting preventing fluid intake

People who stay on tirzepatide at a maintenance dose lose only 2 to 5% of their weight back over the following year, compared to 30 to 50% regain among those who stop