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Notably, while both carbohydrate and fat ingestions induce considerable increase in GIP secretion, plasma GLP-1 levels primarily surge after glucose-rich meals (56) [ Figure 1 Section A]

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However, in murine models, exendin-4 demonstrates about 5,500-fold greater potency in improving glucose control, evidenced by the percentage fall in plasma glucose at 1 hour (87)

However, inhibiting gastric emptying mainly plays a role in reducing postprandial hyperglycaemia, and hence might not be the main mechanism of weight loss (176)

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