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IGF-1 LR3 differs from endogenous IGF-1 in one critical way: the arginine substitution at position 3 prevents binding to IGF-binding proteins (IGFBPs), extending circulation time and allowing the peptide to remain bioavailable far longer than native IGF-1

This concentration gradient makes transport of GSH from outside the cell to inside the cell thermodynamically unfavourable

It maintains testicular function while the HPG axis restores signaling

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Role of the complement system in antibody-dependent enhancement of flavivirus infections