Papers were excluded if they were review papers, if the study was conducted only on animals, if there was no measurement of ghrelin or GLP-1, or administration of an agonist or antagonist for the respective receptors, or when the hormonal measure or manipulation was not related to the reward response
Semaglutide, for example, has FDA-approved cardiovascular benefits for certain patients, while tirzepatide is also approved to treat obstructive sleep apnea in adults with obesity
Animal models do not always translate into humans
Studies in the National Library of Medicine suggest that GLP-1 medications can improve menstrual regularity and ovulation, reduce insulin resistance and androgen levels, and support spontaneous pregnancy after a period of treatment
If a cell type predominates, then the infiltrate should be classified as lymphocytic, plasmacytic, or histiocytic
Overall, modulation of NAD + metabolism and the SIRT pathway may represent promising strategies for delaying ovarian aging