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This is because the life cycle of red blood cells is 90 days

Gain-of-function studies demonstrated that recombinant BDNF mimics might have beneficial effects on NSC transplantation, while loss-of-function studies showed that mice depleted of NSC-derived BDNF failed to improve cognition or restore hippocampal synaptic density (80)

Think of it as: An internal defense shield against aging, illness, and oxidative damage

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It should be used with caution in pediatric patients, particularly those younger than 1 month old, due to limited safety data in this population