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The acupoint stimulation activation exerts multimodal analgesic effects through SDH receptor modulation targeting 5-hydroxytryptamine (5-HT) and N -methyl-d-aspartate receptor 1 systems, concurrent -endorphin expression upregulation, and suppression of algogenic neurotransmitter release pathways [122, 123]

Beneficial during drug administration with salicylate, atropine, ammonium chloride, or barbiturate

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conversely, if they are redundant, the model may overestimate these effects