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A recent study employed single-molecule array (Simoa), an ultra-sensitive technology, to quantitate very low concentrations (picomolar to femtomolar) of -synuclein protofibrils (PFs) in CSF of PD patients and observed an increased concentration of -synuclein PFs in PD patients (von Euler Chelpin et al., 2020)

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Inhibition by pentoxifylline of TNF--stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-B down-regulation