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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

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Highly purified water (typically water for injection, which has undergone multiple distillation or reverse osmosis) is mixed with a precisely measured amount of benzyl alcohol so that the resulting concentration is exactly 0.9% (weight/volume)

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Women run the same dose as men (topical 12% nightly