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Type of study: meta-analysis Number of citations: 13 Year: 2019 Authors: Fengjiao Zeng, Zheng Xiao, Cheng-qiong Wang, Yuan Jiang, Jing Shan, Shanshan Hu, Xiao-Rong Huang, Yu-Hong Tang, X

What to Expect in Month 2 Peak nausea: Weeks 6-8 worst for most patients, especially mornings Food aversions: Foods you loved suddenly repulsive (especially meat, coffee) Early satiety: Feel full after 3-4 bites, physical discomfort if you push it Fatigue increases: Combination of medication adjustment and reduced calorie intake Bowel unpredictability: Constipation one day, diarrhea the next Mental fog: Some patients report difficulty concentrating Research from the New England Journal of Medicine on incretin therapies shows this peak-and-resolution pattern is universal across GLP-1 and GIP agonists

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As previously described 1 , the combination of drugs targeting distinct, non-overlapping pathways has proven effective in enhancing treatment efficacy