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(6) the central role of mitochondrial dysfunction in insulin dysregulation

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Statements Author contributions DA: Resources, Funding acquisition, Formal analysis, Software, Conceptualization, Methodology, Writing original draft, Investigation, Data curation

These diurnal rhythm changes are also evident in at the level of cellular and organ metabolism ( Drug abuse related changes in metabolism would also have negative effects on various body systems due to increased cell damage, increased excitotoxicity, reduced energy production, and lowered antioxidant potential in cells