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However, native IGF-1's therapeutic utility is significantly limited by its tight binding to a family of six IGF-binding proteins (IGFBPs) that sequester over 99% of circulating IGF-1, creating a reservoir that regulates IGF-1 bioavailability, prolongs its half-life, but drastically restricts the amount of free IGF-1 available to bind and activate cell surface IGF-1 receptors

Novo Nordisk (the maker of Wegovy) and Eli Lilly (the maker of Zepbound) have both decreased the price of these weight loss drugs for people who are paying out of pocket or do not have insurance coverage for weight loss drugs

P.S: Wegovy is not recommended for pregnant or breastfeeding women

It easily crosses the BBB and mediates brain processes like increasing neuronal regeneration and boosting glucose metabolism

But most GLP-1 users do not live inside a curve

Ponte Press, Bochum 2003, ISBN 3-920328-45-0